Gemcitabine-induced systemic capillary leak syndrome.

Gemcitabine-induced chronic systemic capillary leak syndrome

A 56-year-old woman presented with anasarca, hypoalbuminaemia and hypotension following cycle 3 day 1 of adjuvant gemcitabine for stage II pancreatic cancer. Due to the temporal nature of presentation, suspicion for gemcitabine-induced capillary leak syndrome was included in the differential diagnosis. Vascular endothelial growth factor levels were elevated at 707 pg/mL (reference range: 9-86 p...

Antagonistic Effect of Low-dose Liquiritigenin on Gemcitabine-induced Capillary Leak Syndrome

Gemcitabine (Gemcitabine), a synthetic pyrimidine nucleoside, could block DNA synthesis and inhibit RNA synthesis to some extent. It is used as the standard chemotherapy for pancreatic adenocarcinoma in stage II, III and IV, although it’s primarily palliative (Lau et al., 2012). As a severe result of the attack by gemcitabineinduced cytotoxicity for capillary endothelial cells (CECs), capillary...

Pulmonary Capillary Leak Syndrome

Systemic capillary leak syndrome associated with compartment syndrome.

Systemic capillary leak syndrome is characterized by recurrent hypovolemic shock attributable to increased systemic capillary leakage. A 26-year-old woman was admitted because of recurrent episodes of hypovolemic shock. Hemoconcentration, hypoalbuminemia, and monoclonal gammopathy were observed. We diagnosed systemic capillary leak syndrome. Three years later, she again had an attack of systemi...

[May-Thurner syndrome: an infrequent cause of spontaneous left iliac vein rupture].

1. Druey KM, Greipp PR. Narrative review: The systemic capillary leak syndrome. Ann Intern Med. 2010;153:90--8. 2. Kapoor P, Greipp PT, Schaefer EW, Mandrekar SJ, Kamal AH, Gonzalez-Paz NC, et al. Idiopathic systemic capillary leak syndrome (Clarkson’s Disease): The Mayo Clinic Experience. Mayo Clin Proc. 2010;85:905--12. 3. Gousseff M, Arnaud L, Lambert M, Hot A, Hamidou M, Duhaut P, et al. Th...